Alidya 5Flac340Mg+5Flac.10Ml Solvent

Description

ALIDYA is a new revolutionary device for the treatment of cellulite.

* The application of the product is reserved exclusively for qualified healthcare professionals.

MEDICAL DEVICE

Alidya is the first injectable solution for the treatment of cellulite, specifically a solution for medical use used in protocols with intradermotherapy, involving physiological and para-physiological alterations related to the origin and progression of gynecoid lipodystrophy (cellulite). It was developed by Prof. Pasquale Motolese and patented worldwide. Indications: treatment of gynecoid lipodystrophy (cellulite), post-liposuction treatment, post-intralipotherapy, lipoedema with or without lymphedema, alterations of the subcutaneous adipose tissue.

The project Alidya aims to ensure a supportive rather than purely functional therapy, using means to correct changes in skin and subcutaneous tissues related to lipodystrophy and atrophy. In fact, these changes clinically manifest as small depressions or dimples on the skin surface, leading to uneven and cracked skin.

The correction of these skin depressions and dimples cannot be achieved with existing absorbable fillers on the market, related to failed attempts with polyacrylic acid which proved to be highly reactive and fibrogenic, creating significant scar tissue. In reality, corrections with gel-like and highly viscous products that release microparticles are technically very difficult.

Alidya , with its special formulation, is destined for superficial subcutaneous tissues and differs from other products because it reacts also in the deeper layers of the skin such as the dermis. Alydia represents a new class of injectable means based on amino acids similar to those already existing on the market, used in youthful skin (Jalupro, Skinr..). The difference is that Alidya's formulation adapts better to the biological environment, whether it concerns a superficial or deeper part of the skin.

Alydia is an injection solution for the external subcutaneous part of the skin, containing components that are rapidly absorbed (within a few hours) and do not contain pharmacologically active substances.

Although there is no other product with a similar indication, there are numerous products with similar composition used for skin biorevitalization and restructuring. The difference with Alidya is that its formulation adapts to osmolarity and pH values in different environments, not just within the dermis.

Medical Evaluation

Clinical research conducted on women aged 28 to 65 showed excellent tolerability of the injectable means with no skin reactions of any kind. Moreover, the first study (35 women treated once a week for up to 7 weeks) showed a high level of satisfaction among the women interviewed, with a desire to repeat the treatment as soon as possible.

Alidya

Alidaya is the first injectable solution for the treatment of cellulite, specifically a solution for medical use employed with protocols involving intradermotherapy, involving physiological and para-physiological alterations related to the origin and evolution of gynecoid lipodystrophy (cellulite). It was developed by Prof. Pasquale Motolese and patented worldwide. Indications: treatment of gynecoid lipodystrophy (cellulite), post-liposuction treatment, post-intralipotherapy, lipoedema with or without lymphedema, alterations of the subcutaneous adipose tissue.

Alidya – Eliminates Cellulite and Achieves Permanent Results

By definition, cellulite is a phenomenon that triggers a chain of negative physical and psychological reactions.

The medical term for cellulite is "ADIPOSIS DEMATOSA".

The development of cellulite is slow and occurs in stages:

• Venous and lymphatic pathway stage: microcirculatory alterations and small blood vessels are spreading in the deep dermis;
• Edematous stage: the drainage system begins to function more slowly, and waste materials are retained within the interstitial space. This causes fluid to pass through blood vessels into tissues, leading to edema. The interstitial space expands, compresses its contents, and drainage decreases, creating a vicious circle;
• Proliferative stage: irregularities disturb the normal flow of nutrients and oxygen. The deprived cells undergo changes in number and size, glycosaminoglycan production enlarges, making the tissue more viscous, and elastic fibers harden, forming a net with the appearance of shapeless fat cells gathered in nodules on the surface;
• Sclerosis stage: nodules become more palpable, reactions and fibrotic scars form, pulling in round formations of the dermis causing an orange peel appearance, the characteristic look of cellulite.

Studies by Dr. Motolese published in the European Journal of Aesthetic Medicine Dermatology at the end of 2011. It addresses the pathophysiological causes of cellulite formation. The most widespread hypothesis relates to the anatomical schematic of fat lobules located in the outer zone of the subcutaneous adipose tissue (hypodermis), which inflames and determines the stage of progression (obstruction), increasing microcirculatory permeability. Identification of potentially toxic elements could cause tissue fibrosis.

Three tissue biopsies taken from three different women showed traces of certain metals, suggesting a presence of toxic metals within the adipose tissue, linked to tissue degeneration that develops in cellulite.

The term cellulite refers to an aesthetic condition mainly affecting women, where changes in skin profile occur, especially in the lower limbs. Its nature is complex and controversial, so limited scientific evidence describes three pathogeneses:

• Circulatory disturbance causing microvascular pathways in the subcutaneous adipose tissue, related to:
• Female hormonal factors that impact chronic tissue inflammation,
• An anatomical structural defect involving the presence of a fibrous septum on the skin surface, with an angular orientation of fat lobules (in men, the orientation is parallel to the skin surface).

During research, biopsies are performed on the anterolateral thighs of three women aged 33, 35, and 40, in order to determine the presence of damaged tissue in the external cellular matrix of the adipose tissue region. The degree of cellulite could be classified as Grade III-IV.

Microscopic examination showed that the adipose tissue consists of cells of different sizes surrounded by a large area of sclerosis, with close presence of iron and hemosiderin.

It is concluded that in the presence of these metals, tissue degeneration occurs through the creation of free radicals, pre-oxidation of lipid adipocyte membranes causing chronic inflammation and tissue acidosis.

This expansion results from vascular permeability, which can be observed in cellulite, and iron produces its toxic and degenerative effects on the subcutaneous adipose tissue, causing an inflammatory state, acidosis, cellular degeneration, and necrosis. It will gradually emerge and cause ongoing damage.

The treatment Alidya promotes removal of the iron chelate produced by EDTA and the amino acid buffer solution with sodium bicarbonate to counteract the alkaline environment and the associated cellular acidosis of the tissue.

ALIDYA Composition

• Polyamino acid gel
• α 1-4 glycoside
• EDTA
• Buffer amino acid composition in bicarbonate correction, osmolarity regulator
• D-glucopyranose: cyclic glucose which generates inter-molecular reactions of the hydroxyl group with the carbonyl carbon in the pyranose form of glucose.

Effect: A mixture of amino acids, a metal chelator, an alkalinizing system connected with the extracellular space, can restore balance in the structure of adipose tissue.

Usage:

• Intradermal: mesotherapy or needle 30G – 4mm, at least 7 applications per week, for a maximum of 12 weeks
• After application, perform drainage
• Avoid using cosmetics on the treated area for at least 12 hours after treatment
• Avoid exposure to high heat and/or cold.

Cellulite Treatment – POLICLINIC Tufet

Conversation with Prof. Pasquale Motolese about new hypotheses on the etiogenetics of cellulite and what we can expect from research in the therapeutic field.

Gynecoid lipodystrophy, known as cellulite, is the most controversial skin condition, with extremely complex pathophysiological mechanisms and clinical features that are not clearly established or fully agreed upon.

Professor Motolese, what is the latest information in the scientific literature?

I don't believe that scientific literature has added anything about the genesis of cellulite. If we ignore our latest research published in EJAMed regarding the presence of hemosiderin and free ions in the interstitial area of the adipose tissue, everything else tends to support the questionable clinical effect of some device technologies on this deficiency.

What are the best treatments to fight cellulite?

Carboxytherapy with effects on arterial microcirculation, old vasotropic mesotherapy, lymphatic drainage techniques, and some other methods are deemed definitely rational. Sometimes, they are not even sufficient for proper nourishment and are clinically acceptable. However, they cannot close the enchanted circle caused by oxidative cell damage, which I consider the real culprit, along with altered biochemical conditions of sclerosis tissue. Then came a new invention called Alidya injections.

What is it?

It is a mesotherapy injection method that is the result of long-standing research and is specifically complex.

What will be the effects?

Administered through multiple targeted activities, it involves various components of the injectable solutions that can subsequently facilitate: solubilization and removal of metallic elements, alkalinization of the interstitial matrix (counteracting hypoxic acidosis), improved cellular oxygenation via relaxation (liberation) of CO2, effects of waste and peroxidase constriction; induction of matrix restructuring through the presence of microstructural amino acid chains following a specific pattern; osmotic balance of intra- and extracellular parts.

They are exerted through the multidirectional action of various device components for injection, which include: merging and removal of metallic elements in the alkalinized matrix space (counteracting hypoxic acidosis), enhancing oxygenation via CO2 discharge with a cleansing and anti-peroxidase effect; inducing a restructured matrix due to micro-structured amino acid chains according to specific sequences; osmotic balancing of the entry and exit points of the section.

Studies in Spain have indicated a reduction of more than a few centimeters in the treatment zones with Alidya.

Does it have lipolytic effect?

Absolutely not. Certain medical conditions involve strong lipedema components, so the reduction in circumference is a reorganization of the extracellular matrix structure. It is also possible to hypothesize a uniform arrangement of the cytostructural architecture of adipose tissue, leading to improved physiological cell and interstitial function thanks to enhanced biochemical and hormonal communication between these two sections. Lipolytic effect, often praised, is never truly achieved by any substance because the metabolic process can only start with endogenous hormonal signals (lipolytically dependent intraadipocyte hormone), which in turn depend on metabolic needs. Moreover, β-receptors known in reliable regions of female body fat are rarely present or completely absent alongside α1 and α2 receptors, so any external signals cannot find their true substrate. Nonetheless, it's important to keep in mind that the progression of fibrosclerotic tissue accompanies tissue atrophy, so cellulite should not be mistaken for excess adiposity even though there is a higher presence of adipose tissue, which should be considered a risk factor from the outset, considering the difficulty of fibrotic tissue and the consequent increase in internal tissue pressure.

In my opinion, this satisfies the missing pathophysiological framework. I explain: the teachings of Curri remain as the foundation, and without them, we certainly will not reach these new phases of discovery. The problem, in my view, is conceptual: the microcirculatory deficit has always been seen at the beginning and end of the manifestation of cellulite. In reality, it is certainly necessary but should be considered an intermediate event. Therefore, for a better understanding of pathogenesis, it should be univocally identified as the factor causing microcirculatory deficit, clearly defined as its consequence. This is the last aspect in which I have focused my intention.

Can you say that the future offers the possibility of complete and definitive treatment of cellulite?

Under current conditions, my answer is no. Future research will probably open new horizons and refine therapeutic strategies, but it must be considered that gynecoid lipodystrophy is a condition for development, and this development leads to irreversible chemico-physical changes. Just as Curri so elegantly and effectively called the evolution of this phenomenon 'regressive abiotic'. Naturally, avoiding sclerosis of adipose tissue is a great challenge, and we can address this with Alidya. Another ambitious and almost utopian goal is to repair already caused damage. Clearly, if one day this result is achieved, therapeutic acts will become much more significant in more severe diseases, which are now encompassed under the umbrella of aesthetic concerns, as everyone distinctly believes.

Some general things about cellulite

Cellulite is a condition affecting a very large population, particularly women, with 95% of cases, versus 5% in men. Over the years, considerable progress has been made in its treatment. Today, for addressing this issue, we have various solutions with the tendency to resolve diseases comprehensively and long-term. The appropriate term to describe cellulite is PEFS (Peinguloadipofibrosclerosis) or liposclerosis, along with the changes that manifest in adipose tissue.

In these areas, there are veins and the lymphatic system. The lymphatic system collects and eliminates waste substances from the body. An imbalance can occur between these two systems, leading to slowed blood flow and fluid retention within the tissues, affecting the entire region. This is cellulite, a series of changes that involve both tissue and connective tissue in certain parts of the body. More precisely, that is, in all aspects, it can be considered as an inflammation affecting the subcutaneous adipose tissue, manifesting with a condition of stagnant fluid called edema (swelling). Over time, cellulite changes and progresses through specific stages. The first stage is associated with the so-called micro pathway of lymph and blood or with unbalanced fluid leakage.

These conditions are followed by four defined stages:

• Decay or stasis phase of the venous and lymphatic system, associated with hypoxia, characterized by poor drainage. This condition results in the classic appearance of orange peel that feels rough and unpleasant to the touch, caused by increased adipocytes and subsequent dissociation of elastic fibers that are no longer attached;
• Infiltrative stage, where the skin begins to appear more dehydrated and fragile. This stage involves the perception of nodules and increased tenderness to touch;
• Fibrosis emergence stage, where cellulite begins its path toward the dermis or deeper layers of the skin. During this stage, carbohydrate elimination becomes blocked, often associated with diet and weight loss, and also with lymphatic system blockage. Aesthetic-wise, nodules transform into larger macronodules;
• Scar tissue or fibrosis stage, where dermal fibers become much denser due to accumulated waste, which cannot be eliminated because of fluid stagnation like water and fat. This phase manifests as swelling on the skin and leads to degenerative changes noticeable in early stages. It causes significant pain, worsened by localized cold sensation, spreading out, and stemming from the weight affecting the area.

Factors for the onset of cellulite

To understand possible solutions for cellulite, it is necessary to understand what makes cellulite appear and its main causes related to genetic factors and lifestyle. Addressing cellulite requires first recognizing that its triggers are not single but involve multiple interconnected factors.

Factors are divided into:

• Primary factors, which are not dependent on the individual’s choice or behavior. They relate to gender, race, and genetics. Women, in general, are more prone to cellulite. White women are more affected because they are more sensitive due to the functionality of estrogens on specific receptors in their body composition. The genetic aspect of cellulite is notable because the family is the primary cause of its appearance. If the mother or grandmother suffers from it, it is very likely to manifest in subsequent generations of the female population.
• Secondary factors, related to specific diseases. They are particularly linked to the use of certain medications that inhibit proper circulation and contribute to the sedimentation of fluid layers in the dermis, leading to the condition. These factors are associated with hormone application and contraceptive methods such as pills.
• Aggravating circumstances related to lifestyle and therefore modifiable. These include poor and unbalanced diet, weak and inadequate food, and excessive salt and fat intake. Smoking and alcohol consumption reduce water retention and are major contributors to cellulite formation. This is compounded by a sedentary lifestyle with little movement, maintaining the same habits, and not adopting healthier lifestyles or more physical activity.

What can we do to eliminate cellulite?

Today, aesthetic medicine offers various tools to combat this problem. Since causes of cellulite can be numerous and often coexistent, therapy should target multiple fronts. As noted above, a healthy diet and light physical activity are essential to combat cellulite, especially in maintenance phases. Various complementary techniques are used depending on the patient's baseline conditions. Due to sample diversity, usually one treatment type alone is not effective.

The Usual Treatment Today for Cellulite

Mesotherapy has certainly been one of the most widespread therapeutic acts over the years. Today, some consider it somewhat “old” due to the lack of efficiency and commercial promotion of electrical treatments with better results and greater comfort for clients. However, starting from October, with the market introduction of ALIDYA, the new Italian preparation specially studied and produced for cellulite, mesotherapy has definitely regained its significance.

Virtual mesotherapy is an extremely efficient tool. It is a system for transdermal application of cosmetic products, mostly natural-based, but also medicinal, or even more often a combination of both through specific charged electrical features.

Cavitation is the medical use of low-frequency ultrasound, usually about 40 kHz. It is mainly used to treat localized adiposity because it can dissolve fat cells and reduce the thickness of the adipose tissue. Its depth of action is about 2 cm, and this ability to break down subcutaneous fat tissue has a very positive influence on cellulite.

Radiofrequency acts on specific high-frequency electrical currents, capable of deep action on adipocytes with biophysical performance of electric energy as heat. It causes a reduction of existing collagen fibers and skin tightening, while also promoting the formation of new collagen (“neo-collagenase”). At the same time, it improves microcirculation. It effectively acts on all three pathophysiological causes of cellulite: reducing lipocyte volume, enhancing microcirculation, and regenerating connective tissues so that the skin appears rejuvenated and firm.

Lymphatic drainage device is a massage technique that significantly improves lymphatic fluid circulation, essential for detoxification procedures. It is also necessary for treating edema, especially in the lower limbs.

The removal of lymphatic blockage has a highly positive effect in the treatment of cellulite, eliminating one of its causes.