Armolipid Plus 60Cpr

ARMOLIPID PLUS 60 TABLETS

BLISTER 60 TABLETS

ROTTAPHARM

ArmoLIPID
          PLUS

ArmoLIPID PLUS is a product that brings together in a single formulation natural active ingredients for the control of blood lipids (policosanol, red yeast rice, and berberine), homocysteinemia (folic acid), and antioxidants (coenzyme Q10 and astaxanthin).
The synergistic action of policosanol, red yeast rice, and berberine allows a reduction of plasma levels of total cholesterol, LDL cholesterol, and triglycerides.
The formulation of ArmoLIPID PLUS is completed with a pool of natural substances with antioxidant action (coenzyme Q10 and astaxanthin) which, by integrating into the diet, help counteract endogenous and exogenous free radicals and the peroxidation of blood lipids.

Policosanol is a mixture of natural fatty alcohols found in the waxy matrix of sugarcane, rice bran, and beeswax. The policosanol contained in ArmoLIPID PLUS is extracted from the waxy matrix of sugarcane (Saccharum officinalis) using supercritical carbon dioxide, a process that preserves the original plant chemical structures while avoiding the use of chemical solvents. Policosanol inhibits the biosynthesis of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase, the enzyme responsible for the synthesis of mevalonate, from which endogenous cholesterol arises. Moreover, policosanol promotes the elimination of blood LDL, increasing their hepatic recapture and metabolism. In extensive clinical studies at various dosages, policosanol has lowered total cholesterol and LDL cholesterol and has increased HDL cholesterol. In all clinical studies conducted to date, policosanol has always been well tolerated.

Red yeast rice is produced by fermenting rice (Oryza sativa) with a particular strain of Monascus purpureus and has cholesterol-controlling effects. The active principles of red yeast rice are primarily represented by monacolins, which inhibit HMG-CoA reductase and thus the synthesis of mevalonate from acetate. The biosynthesis of mevalonate is the fundamental and limiting reaction for the synthesis of endogenous cholesterol, and through this mechanism, monacolins reduce blood cholesterol. Experimental and clinical studies have shown that red yeast rice significantly reduces total cholesterol and LDL cholesterol.
The synergy of the mechanism of action of policosanol and red yeast rice on the inhibition of cholesterol production (inhibition of HMG-CoA-r synthesis by policosanol and competitive inhibition with HMG-CoA-r by monacolins) has suggested the clinical use of the combination policosanol (10 mg) + red yeast rice (200 mg equivalent to 3 mg of monacolin) as a dietary supplement for controlling cholesterol levels.

The results of controlled and large-scale clinical studies in everyday clinical practice have highlighted the effectiveness of policosanol + red yeast rice in significantly reducing total cholesterol and LDL in subjects with abnormal cholesterol levels (total cholesterol >190 mg/dL or LDL cholesterol >150 mg/dL). Over a 16-week treatment period, the progressive and consistent reduction of total and LDL cholesterol levels and the increase in HDL cholesterol were significant in favor of policosanol + red yeast rice as early as the fourth week, reaching 17.9% for total cholesterol and 18.8% for LDL cholesterol. In the subpopulations of patients coming from previous treatment with statins, diabetic patients, and obese hypercholesterolemic patients, an effectiveness on individual cholesterol indices comparable to that of the general population was observed. The tolerability of policosanol + red yeast rice, documented in over 2000 treated cases in Italy, was excellent.

Berberine is a natural plant preparation extracted from the bark of Berberis aristata. In vitro and in vivo studies have shown that berberine increases the expression of LDL receptors by enhancing messenger RNA levels. Berberine does not appear to be involved in the transcriptional process, but acts by increasing the stability of messenger RNA for LDL receptors (mRNA LDLR). The increased availability of LDL receptors results in greater hepatic recapture of plasma cholesterol, reducing plasma levels of total cholesterol and LDL cholesterol. Additionally, berberine inhibits the synthesis of triglycerides through AMP-activated protein kinase (AMPK).

The activation of this enzyme indeed leads to the phosphorylation and subsequent inactivation of acetyl coenzyme A carboxylase (ACC), a key enzyme in triglyceride synthesis.
Controlled clinical studies have shown that berberine significantly reduces plasma levels of total cholesterol, LDL cholesterol, and triglycerides.
Berberine has not altered liver or kidney function and has been well tolerated.

The subdeficiency of folic acid is now the most widespread form of hypovitaminosis in the Western world and is due to the unbalanced diet imposed by modern life.
Folic acid is necessary for the methylation of homocysteine and its conversion into methionine. A deficiency of folic acid causes hyperhomocysteinemia, which is an important cardiovascular risk factor.
ArmoLIPID PLUS covers the daily physiological requirement of folic acid, i.e., 0.2 mg, compensating for any situations of deficiency or subdeficiency of folic acid. At this dose, folic acid is optimally tolerated and is useful for controlling homocysteinemia and enhancing the eulipemic effects of the triad policosanol, red yeast rice, and berberine.

CoQ10 is a physiological component of our body that participates in the redox reactions involved in ATP synthesis and is therefore necessary for all chemical and mechanical energy processes. CoQ10 is particularly useful for protecting the heart from stress, even in aging.

Astaxanthin is a powerful natural antioxidant, with antioxidant activity 10 times greater than that of β-carotene and 100-500 times greater than that of vitamin E. Astaxanthin prevents the peroxidation of plasma lipoproteins and eliminates one of the factors that cause arteriosclerosis. Astaxanthin thus exerts a synergistic eulipemic effect with those of policosanol, red yeast rice, berberine, and folic acid, strengthening the protective action of coenzyme Q10.

Astaxanthin, at the dose contained in ArmoLIPID PLUS, is well tolerated and does not require special precautions for use.
The activation of this enzyme indeed leads to the phosphorylation and subsequent inactivation of acetyl coenzyme A carboxylase (ACC), a key enzyme in triglyceride synthesis.
Controlled clinical studies have shown that berberine significantly reduces plasma levels of total cholesterol, LDL cholesterol, and triglycerides.
Berberine has not altered liver or kidney function and has been well tolerated.

The nutrients of ArmoLIPID PLUS exert cholesterol and triglyceride-controlling effects, supplementing an overall adequate diet for this purpose.