NOMETFOR 15CPS

Description
Dietary supplement containing carcinine, anti-glycation, de-glycation and anti-aging.
Inhibition of the synergy between glycation and oxidation reactions.
Halt of scavenging propagators (glucose, methylglyoxal, etc.).
Inhibition of lipid peroxidation.
Chelation of metal ions.
Treatment of anti-aging skin.
Usage:
-internal medicine: metabolic syndrome, diabetic complications, obesity;
-gynecology: polycystic ovary syndrome (PCOS);
-dermatology: anti-age (publication on Carcinina at the 24th World Congress of Dermatology-Milan 2019);
-Ophthalmology: cataract, retinal degeneration.

Properties
Carcinine is more stable than carnosine, is not attacked by the enzyme carnosinase, nor converted into histidine. It is rapidly absorbed, resistant to gastric pH, skin peptidases, serum and tissue peptidases. It has a longer duration in the body, allowing it to improve its effectiveness against glycation.

Ingredients
Glycoless (dichlorohydrate of carcinine), Lithotame (Lithothamnion calcareum Areschoug) stem powder, magnesium stearate, chromium picolinate, vegetable gelatin capsule (E171).

Nutritional characteristics

Average values per 1 capsule
Glycoless	200 mg
Lithotame	200 mg
Magnesium stearate	2 mg
Chromium picolinate	1.66 mg

Method of use
1 capsule to be taken in the morning on an empty stomach.

Storage
Store at a temperature not exceeding +25°C.
Shelf life when unopened: 36 months.

Format
Pack of 15 capsules.

Code NOM

Bibliography
1. "The role of carcinine treatment on glycolipid imbalance of overweight and obese woman", Palmieri B., Pepe V., Simas L.a.w., Granzoti R., Novak B., Wolpe R.e., Zilbert B., Yamaguchi E.m., Vadalà M., Department of General Surgery and Surgical Specialties, University of Modena and Reggio Emilia Medical School, Surgical Clinic.
2. "A supplementation of carcinine and its implication on fasting blood sugar, glycated hemoglobin, insulin, fructosamine and lipid profile in women with overweight and obesity: a randomized double-blind controlled trial". Simas, l.A.W.; Granzoti; r.; Novak, b; wolpe, r.E.; Zilbert, b.; Yamaguchi, e.M.
3. "L-Carnosine(-alanyl-L-histidine) and carcinine F-alanylhistamine) act as natural antioxidants with hydroxyl-radical-scavenging and lipid-peroxidase activities", Mark A. Babizhayev, Marie-Christine Seguin, Jean Gueynej, Rima P. Evstigneeva, Elena A. Ageyeva and Galina A. Zheltukhinai, Moscow Helmholtz Research Institute of Eye Diseases, Russia, and IM.V. Lomonosov Institute of Fine Chemical Technology, Russia, Exsymol S.A.M., Monaco, Principality of Monaco.
4. "Carcinine Has 4-Hydroxynonenal Scavenging Property and Neuroprotective Effect in Mouse Retina", Lea D. Marchette, Huaiwen Wang, Feng Li, Mark A. Babizhayev, Anne Kasus-Jacobi, Departments of Ophthalmology, Molecular Biology Proteomics Facility, and Pharmaceutical Sciences, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma.
5. "Investigating Carcinine Transport and the Expression Profile of Transporter Genes in Human Corneal Epithelial Cells", Studies on the Cornea and Lens, pp 131-144, Anne Kasus-Jacobi (Department of Pharmaceutical Sciences and Oklahoma Center for Neuroscience), Vibudhuta Awasthi (Department of Pharmaceutical Sciences, University of Oklahoma Health Sciences), Mark A. Babizhayev (Innovative Vision Products Inc., Moscow, Russia), H. Anne Pereira (Departments of Pharmaceutical Sciences, Pathology, and Cell Biology and Oklahoma Center for Neuroscience, University of Oklahoma Health Sciences Center, Oklahoma City, USA).
6. "Treatment of Skin Aging and Photoaging with Innovative Oral Dosage Forms of Non-Hydrolized Carnosine and Carcinine", Research Article ,International Journal of Clinical Dermatology & Research (IJCDR), Babizhayev Mark A. (Innovative Vision Products, Inc).
7. "Advanced Glycation End-Products and Their Receptor- Mediated Roles: Inflammation and Oxidative Stress", Parisa Younessi, Ali Yoonessi, Iran J Med Sci, September 2011; Vol 36 No. 3.
8. A. Pegova, "Comp. Biochem. Physiol.", vol. 127, (2000). pp. 443-446.